Recombinant Blood Group Protein Products
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Soluble Recombinant Cluster of Differentiation 38 Protein [CAT#: REK8-K2]
Soluble Recombinant Cluster of Differentiation 35 Protein [CAT#: REK8-K1]
For the even more common situation with clinically irrelevant antibodies against high-frequency antigens, the distinction between "crippled" and "extra sensitive" high-frequency antibodies can be challenging in patients requiring blood transfusions due to numerous clinically significant blood group-specific antibodies. Creative Biolabs provides excellent recombinant blood group proteins as well as custom services for clients around the world. Soluble recombinant (sr) proteins, specifically exhibiting characteristics of the blood group antigen, can inhibit the hemagglutination caused by these more or less irrelevant antibodies. This inhibition contributes to the exact identification of real significant antibodies. In reality, the patient serum or plasma is incubated with Sr proteins before incubation of acceptable sample to panel red blood cells which may be determined by either Gel or Tube IAT for inhibited whole blood.
Introduction
The role of blood group antigens is critical components at the surface of red blood cells (RBCs) and have major implications in transfusion medicine, transplantation and immunological investigations. Antigens for blood types and effect on immune reactions These antigens are traditionally studied/used from donor materials for blood group antigens deducing with difficulties in availability, purity, and batch reproducible.
Recombinant Blood Group Proteins provide a robust platform to produce naturally occurring RBC antigens with functionality equivalent to the native one. These proteins are vital to applications including, but not limited to, blood typing, immunoassays, and immune interaction studies.
Both srCD35 and srCD38 are designed to inhibit the agglutination of red cells in immunohematological assays. srCD35 de facto blocks CR1 related agglutination irrelevant to antibodies of red cell lineaments and srCD38 can neutralize the red cell agglutination due to therapeutic anti-CD38 monoclonal antibodies. This soluble form ensures good reactivity in both gel and tube agglutination assays for the researcher to have a consistently high purity reagent for research.
Products
Features
- Soluble Recombinant Cluster of Differentiation 35 Protein (Cat#: RIK8-K1): This product contains a mixture of two soluble recombinant CR1 proteins designed to inhibit red cell agglutination caused by CR1-related antibodies. It works well in agglutination tests in tubes and gels. A single vial can have up to 12 inhibition reactions and the need for -20°C storage upon receipt.
- Soluble Recombinant Cluster of Differentiation 38 Protein (Cat#: RIK8-K2): In both gel and tube agglutination tests, this reagent prevents red cell agglutination brought on by therapeutic anti-CD38 monoclonal antibodies. One vial of srCD38 is sufficient for 6 consecutive inhibition reactions; after delivery, it should be stored at -20°C.
- High Purity – Advanced purification techniques ensure exceptional purity, reducing background noise in assays and improving reliability.
- Batch-to-Batch Consistency – Stringent quality control guarantees reproducibility across different production lots.
- Customizable Options – Available with tailored tags, buffer formulations, and concentrations to meet specific research needs.
- Comprehensive Documentation – Each product includes a certificate of analysis (CoA) and detailed quality reports for transparency and confidence.
Customer Reviews
FAQs
Q: What are soluble recombinant blood group proteins applied for?
A: Soluble recombinant blood group proteins like srCD35 (and srCD38) which is used to scavenge red cell agglutination by minor antibodies, nuisance antibodies, or therapeutic monoclonals. This allows accurate detection of immunoglobulin in an immunohematology assay for clinically relevant antibodies.
Q: What should I do with these recombinant blood group proteins in my experiments?
A: First, you incubate the recombinant. It will have differential levels of the anti-interfering antibodies against patient serum/plasma and your test. The treated sample can be used in a red blood cell (RBC) panel for the detection of immunologically significant antibodies after the incubation.
Q: What is the shelf life of the product (after opening)?
A: The products are stable for storage at -20°C until expiry, as marked on the label, when stored properly. Re-use: aliquot after thawing and use immediately. For all the specific stability information, read the supplementary certificate of analysis (CoA).
Q: Can I order these outside of the USA?
A: Indeed, we ship internationally. For customs clearance, fees may vary per country and must be covered by the customer.
Q: Discount for bulk purchasing?
A: Yes, we have bulk purchase discounts. Please reach our sales team for pricing and availability of the product.
