Online Inquiry
Soluble Recombinant Cluster of Differentiation 35 Protein
Cat. No.: REK8-K1
Note: The listed price does not include duties, taxes, or shipping & handling fees.
Inquiry Now
Bulk or Custom Request
Prevent red blood cell agglutination caused by CR1-related antibodies in gel and tube agglutination tests.
| Details | |
|---|---|
| Application | Red cell agglutination inhibitor |
| Description | Prevent red blood cell agglutination caused by CR1-related antibodies in gel and tube agglutination tests. |
| Conjugation | Unconjugated |
| Reactions/Vial | 12 inhibition reactions/vial |
| Form | Liquid |
| Storage/Stability | Under -20°C |
| Shipping | Ice Pack |
| Overview | |
|---|---|
| Overview |
CD35 (complement receptor 1, CR1) is a regulatory glycoprotein of approximately 200 kDa, found on red blood cells as well as various other blood cells and cell types. In plasma, CR1 also exists in a soluble form. Chromosome 1 contains the gene that codes for CR1. The 30 amino acid homology sections that make up the CR1 polypeptide's extracellular domain are referred to as short consensus repeats (SCRs) or complement control protein (CCP) repeats. Each CCP domain contains four cysteine residues, with its structure stabilized by two disulfide bonds. Each of the four structural domains known as long homologous repeats (LHRs), which are made up of seven CCPs, is formed by the aggregate of the 28 most N-terminal CCPs. Knops blood group system polymorphisms, including KN1/2 (Kna/b), KN3/6 (McCa/b), KN4/7/8 (Sl1/2/3), and KN5 (Yka), are linked to single nucleotide polymorphisms in the CR1 gene, namely at CCP 22 or 25 of LHR-D. Due to the structural similarity between LHR-D and LHR-C, some antibodies from the Knops system show varying levels of reactivity with both protein regions. Consequently, a blend of srCR1-LHR-C and srCR1-LHR-D effectively neutralizes antibodies targeting the common antigens of the Knops blood group system. |
