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Soluble Recombinant Cluster of Differentiation 38 Protein
Cat. No.: REK8-K2
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Prevent therapeutic anti-CD38 monoclonal antibodies from causing red blood cell agglutination in both gel and tube agglutination tests.
| Details | |
|---|---|
| Application | Red cell agglutination inhibitor |
| Description | Prevent therapeutic anti-CD38 monoclonal antibodies from causing red blood cell agglutination in both gel and tube agglutination tests. |
| Conjugation | Unconjugated |
| Reactions/Vial | 6 inhibition reactions/vial |
| Form | Liquid |
| Storage/Stability | Under -20°C |
| Shipping | Ice Pack |
| Overview | |
|---|---|
| Overview | CD38 (cyclic ADP ribose hydrolase) is a type II membrane glycoprotein that is widely expressed on the surface of red blood cells. The CD38 gene is located on chromosome 4. Soluble CD38 (srCD38) represents the extracellular domain of human CD38 and is notably abundant in hematological malignancies, particularly multiple myeloma, making it a target for monoclonal antibody therapies. However, anti-CD38 therapies can complicate routine serological testing and compatibility assessments, as these antibodies also attach to CD38 on red blood cells. Consequently, plasma or serum samples from patients receiving anti-CD38 therapy may react broadly with red blood cell panels, leading to positive auto-antibody controls in indirect antiglobulin tests (IATs). This pan-reactivity can obscure the detection of clinically significant antibodies, although it can be mitigated through the adsorption of the therapeutic antibody using srCD38, which does not react with clinically significant red blood cell antibodies. Another approach to reducing interference from therapeutic anti-CD38 antibodies in serological testing involves treating panel red blood cells with dithiothreitol (DTT). DTT disrupts protein disulfide bonds, preventing the binding of therapeutic antibodies to red blood cells, but it also inactivates other antigens. |
